New DNA Biosensor Could Unlock Powerful, Low-Cost Clinical Diagnostics
Jan. 24, 2023 By flagging disease-associated DNA biomarkers, medical professionals can make early diagnoses and provide personalized treatments, but the typical screening methods can be laborious, expensive or …
Gene Expression Study Reveals New Molecular Associations With Obesity
Jan. 18, 2023 Researchers highlight new insights in gene expressions associated with body mass …
Scientists Developing Early Alzheimer’s Disease Detection Sensor
Jan. 18, 2023 Researchers are developing a new biosensor that can be used to screen for Alzheimer’s disease and other …
Inner Ear Has a Need for Speed
Jan. 18, 2023 Scientists and engineers have modeled a hidden mechanism in the inner ear that helps mammals balance via the fastest-known signal in the …
Researchers Identify Therapeutic Targets to Overcome Radioresistance of Brain Cancer Cells
Jan. 18, 2023 Glioblastoma (GBM) is a WHO grade IV brain tumor with dismal prognosis. Although post-surgical radiation chemotherapy combined with temozolomide is the standard line of treatment, GBM cells surviving …
Modified CRISPR-Based Enzymes Improve the Prospect of Inserting Entire Genes Into the Genome to Overcome Diverse Disease-Causing Mutations
Jan. 17, 2023 Many genetic diseases are caused by diverse mutations spread across an entire gene, and designing genome editing approaches for each patient’s mutation would be impractical and …
Combining Multiple Maps Reveal New Genetic Risk Factors for Blindness
Jan. 17, 2023 Combining a map of gene regulatory sites with disease-associated loci has uncovered a new genetic risk factor of adult-onset macular degeneration (AMD), according to a new study. The finding advances …
In Cells, UV-Emitting Nail Polish Dryers Damage DNA and Cause Mutations
Jan. 17, 2023 The ultraviolet nail polish drying devices used to cure gel manicures may pose more of a public health concern than previously thought. Researchers studied these ultraviolet (UV) light-emitting …
Researchers Create New System for Safer Gene-Drive Testing and Development
Jan. 17, 2023 Researchers have developed a new system for developing gene drives for areas ranging from human health to global food supplies. The new ‘hacking’ system converts split gene drives into full …
New Research Furthers Case for Exercise Promoting Youthfulness
Jan. 17, 2023 Researchers compared aging mice that had access to a weighted exercise wheel with mice that had undergone epigenetic reprogramming via the expression of Yamanaka factors. Ultimately, the team …
Resistance Training in Older Adults at the Cellular Level
Jan. 17, 2023 Aging and related diseases are associated with alterations in oxidative status and low-grade inflammation, as well as a decreased endoplasmic reticulum (ER) unfolded protein response (UPR). UPR is a …
Optimal Genome Mapping Offers High-Resolution Method to Better See, Then Target Cancer-Causing Gene Variants
Jan. 17, 2023 Technology that enables an unprecedented, high-resolution look for all structural variants in our genes that are known to cause cancer can outperform standard tests used today for common blood …
Researchers Produce Toolkit for RNA Sequencing Analysis Using a ‘Pantranscriptome’
Jan. 16, 2023 Researchers introduce a method for analyzing RNA sequencing data genome-wide using a ‘pantranscriptome,’ which combines a transcriptome and a pangenome, creating a richer reference that can …
Highly Accurate Test for Common Respiratory Viruses Uses DNA as ‘Bait’
Jan. 16, 2023 A new test ‘fishes’ for multiple respiratory viruses at once using single strands of DNA as ‘bait’, and gives highly accurate results in under an …
Machine Learning Method Improves Cell Identity Understanding
Jan. 13, 2023 When genes are activated and expressed, they show patterns in cells that are similar in type and function across tissues and organs. Discovering these patterns improves our understanding of cells — …
Using Paleogenomics to Elucidate 10,000 Years of Immune System Evolution
Jan. 13, 2023 Scientists have used paleogenomics to trace 10,000 years of human immune system evolution. They analyzed the genomes of more than 2,800 individuals who lived in Europe over the past ten millennia. …
Madagascar Mouse Lemur Retroviruses Are Diverse and Surprisingly Similar to Ones Found in Polar Bears or Domestic Sheep
Jan. 13, 2023 Madagascar is home to a unique biodiversity with a large number of endemic species, among those many lemur species, including the mouse lemurs. This diversity is also found in their retroviruses. …
Scientists Take Another Step Toward Building a Better Pain Killer
Jan. 12, 2023 New work provides a comprehensive structural framework that should help drug developers rationally design safer drugs to relieve severe …
Overactive Cell Metabolism Linked to Biological Aging
Jan. 12, 2023 Human cells with impaired mitochondria ramp up their metabolism to enhance short-term survival, but at a cost: more rapid …
Why Older Fathers Pass on More Genetic Mutations to Their Offspring
Jan. 12, 2023 It’s not just the number of mutations that matters. It’s the failure to fix them …
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