Prairie voles still form social bonds without oxytocin sensors in the brain. The findings challenge the long-held belief that the hormone is a crucial part of the bonding process for all mammals
27 January 2023
Monogamous prairie voles lacking receptors for the “love hormone” oxytocin still bond with their mates and their young – contradicting long-held assumptions about how essential the hormone is for these behaviours.
Also known as the “cuddle chemical”, oxytocin is released in our brains during moments of romantic intimacy, parenting and other forms of social bonding, as well as during labour and lactation. Scientists have spent decades studying the hormone’s role in the brains of many mammal species, including the prairie vole (Microtus ochrogaster). These voles have been particularly interesting to researchers because, unlike other laboratory animals such as mice and rats, prairie voles show intense attachment to one long-term partner, a behaviour called pair bonding.
For decades, pharmacological studies suggested that oxytocin receptors – the proteins studding the outside of cells where oxytocin molecules attach – were essential to produce bonding behaviours. So when Devanand Manoli at the University of California San Francisco and his colleagues removed oxytocin receptors in prairie voles by using the CRISPR gene editing technique, they were shocked to find that the animals still pair bond.
Manoli still remembers the moment co-author Kristen Berendzen walked into the lab to tell him the news. “We were floored,” he recalls.
Prairie voles lacking oxytocin receptors were also able to give birth and nurse their young, spending long periods of time grooming and huddling with them. The voles behaved very much like prairie voles that still had their oxytocin receptors intact.
However, vole pups born to mothers lacking oxytocin receptors weighed significantly less by the time they reached weaning age, suggesting that the mother had issues with milk production or nursing. They were also less likely to survive to weaning age. So, although pair bonding and other important social behaviours were not impacted, oxytocin receptors still seemed to play a substantial role in vole pup development.
“What I love about this paper is that, yes, it’s looking at partner preference in particular, but there are also these major questions about childbirth and child rearing,” says Robert Froemke at New York University Grossman School of Medicine. “These fundamental processes of birth and nursing that make us mammals are so woefully understood.”
Manoli says that, once the initial shock wore off, the findings made more sense.
“It’s not surprising that there isn’t a single point of failure for behaviours as important to a species as attachment,” he says. A more complex system could also explain the failure of past clinical trials of oxytocin in people with social anxiety disorder, schizophrenia and other conditions. Such trials aimed to alleviate issues people were experiencing forming social attachments and appropriately processing social situations.
“When the implications from pharmacology first came out, there was this hope that oxytocin could be a major therapeutic intervention,” says Manoli. But the trials yielded inconsistent results with no dramatic patient improvements in social behaviours. It could be that oxytocin is just one part of a hormonal mosaic behind bonding.
Manoli and his colleagues are considering what chemical processes in the brain might be compensating in the absence of oxytocin receptors, or if oxytocin might even be binding to other receptors in the brain to make crucial social attachments possible.
More on these topics:
Source link Recent studies have cast doubt on the role of the so-called ‘love hormone’ oxytocin in social bonding. For years, oxytocin has been thought to be a crucial factor in promoting social connection and attachment, but a new study has suggested that this may not necessarily be the case.
The study, conducted by an international team of scientists, found that raising oxytocin levels did not necessarily lead to increased social behaviour. Rather, the participants’ levels of sociability were determined by the context of the situation, and the levels of oxytocin present did not appear to be a major factor.
Previous research has suggested that oxytocin plays a key role in bonding between people, and has even been associated with increased levels of trust and feelings of attachment. But the new findings suggest that, while oxytocin may be important in some situations, it is not necessarily needed for social behavior.
The researchers stress, however, that further research is needed to understand the full impact of oxytocin. While their study did not find any direct evidence of a role for oxytocin in social behavior, it is possible that the hormone may still have some indirect effects.
In any case, the study provides an important reminder that a variety of factors are involved in social bonding. Oxytocin may still be included among them, but it is important to recognize that it is only one of many potential influences, and that its role is far from clear-cut.