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Skin Cancer News — ScienceDaily

Awakening ‘Dormant’ Cells to Fight Cancer

The advent of small-molecule targeted therapies, a decade ago, revolutionized the treatment of metastatic melanoma, provided that the tumors carry the mutations to respond to these treatments. …

Tumors Form Temporary Structures to Avoid Immunotherapy Treatments

Scientists have shown how tumor cells evade immunotherapy by generating unique, temporary cell-in-cell structures, where the inner cells remain in tact and can return to single tumor …

Scientists Identify Key Biomarkers That Reliably Predict Response to Immune Checkpoint Inhibitor Therapy for Melanoma

Currently, the only FDA approved biomarker for ICI melanoma treatment is the tumor mutation burden assay, but the mechanisms linking it to ICI remain unclear. However, new research now provides …

Melanoma Treatment: Potential Target Bypasses Therapeutic Resistance to Immune Checkpoint Blockers

Over the last decade, immune checkpoint blockers, or ICBs, have revolutionized treatment for various advanced cancers, including melanoma, the most aggressive skin cancer that was considered largely …

Identifying Melanoma Patients With High-Risk Disease

Medical researchers report on their identification of high-risk patients with stage 3A disease and microscopic lymph node metastases who would benefit from adjuvant …

Targeted Cancer Vaccines Eliminate Tumors and Prevent Recurrence in Mice

Researchers developed a lipid nanoparticle-delivered cancer vaccine against a mouse model of melanoma that specifically targets the lymph system to generate greater potency. They were able to achieve …

Melanoma Thickness Equally Hard for Algorithms and Dermatologists to Judge

Assessing the thickness of melanoma is difficult, whether done by an experienced dermatologist or a well-trained machine-learning algorithm. A study shows that the algorithm and the dermatologists …

Researchers Discover DNA Copy Number Alterations Lead to Changes in RNA Circuits That Impact Melanoma Metastasis

Most cancer research and available anticancer drugs focus on the impact of DNA and protein alterations that contribute to cancer; however, it is now understood that RNA molecules can also both …

Take the Burn out of Sunscreen Testing: Experts

Exposing humans to ultraviolet radiation to test sunscreen effectiveness should be phased out, according to scientists and cancer …

Study Identifies Unique Underlying Molecular Factors Driving Melanoma Development

A new study reveals important molecular information that could help scientists develop more effective treatment and prevention strategies for a difficult-to-treat form of melanoma skin …

Plant Virus Plus Immune Cell-Activating Antibody Clear Colon Cancer in Mice, Prevent Recurrence

A new combination therapy to combat cancer could one day consist of a plant virus and an antibody that activates the immune system’s ‘natural killer’ cells, shows a new study. In mouse …

Androgen Receptor Signaling Contributes to Targeted Therapy Resistance in Melanoma

Androgen receptor (AR) signaling affects response to BRAF/MEK inhibitor therapy in both males and females with melanoma, researchers have shown. The findings provide a new target to combat …

Health: Higher Fish Consumption May Be Associated With Increased Melanoma Risk

Eating higher levels of fish, including tuna and non-fried fish, appears to be associated with a greater risk of malignant melanoma, suggests a large study of US …

Age-Related Lung Changes Provide Pathway for Metastatic Growth of Dormant Melanoma Cancer Cells

New laboratory research finds that secreted age-induced changes in distant sites such as the lung can effectively reactivate dormant cells and cause them to …

Degrading a Key Cancer Cell-Surface Protein to Invigorate Immune Attack on Tumors

One powerful way cancer cells defend against tumor-killing immune cells is to load up their cell surface with a protein known as PD-L1. Now a team of researchers has identified a method to degrade …

Discovery Could Lead to Better Cancer Immunotherapy

A type of white blood cell previously known only as a helper in the immune system appears also to be the instigator of the body’s defenses against cancerous tumors. The discovery could lead to …

T Cell Behavior Determines Which Tumors Respond to Treatment

Immunotherapy unleashes the power of the immune system to fight cancer. However, for some patients, immunotherapy doesn’t work, and new research may help explain why. When immune cells called T …

Spatial Maps of Melanoma

Melanoma is a somewhat unusual cancer — one that blooms before our very eyes, often on sun-exposed skin, and can quickly become deadly as it turns our own skin against us and spreads to other …

Scientists Discover Gene Mutation That Signals Aggressive Melanoma

Mutation of a gene called ARID2 plays a role in increasing the chance that melanoma, a deadly skin cancer, will turn dangerously metastatic, researchers …

Hands, Feet, and Fins: The Connection That Explains Acral Melanoma

Scientists are using zebrafish to understand human skin cancer that attacks the hands and …

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Source link New developments in skin cancer treatments are the focus of a new research findings just released in ScienceDaily. The study, conducted by researchers at the Johns Hopkins Kimmel Cancer Center and published in the Proceedings of the National Academy of Sciences, provides new insight into the genetic and molecular pathways that drive skin cancer.

The team from the Kimmel Cancer Center had already identified a number of cellular components that are involved in the development of skin cancer and now have identified a new protein, AKT1. This protein is believed to be critically important for the development of melanoma, a type of skin cancer.

The researchers used cells from 13 different skin cancer patients to look at the behavior of the AKT1 protein. They discovered that it has a role in controlling the growth, invasiveness and proliferation of tumor cells. Additionally, they found that mutations in the AKT1 protein can lead to the formation of tumors.

The team from the Kimmel Cancer Center is hopeful that their findings can lead to the development of new treatments for skin cancer. One potential therapy that is currently being developed involves targeting AKT1 in order to prevent or reduce the growth in malignant melanoma cells.

Other potential therapeutic strategies are also being explored, including drugs that can inhibit the AKT1 protein. If successful, these treatments could help to slow down or even stop the progression of skin cancer. In addition, the researchers believe that their findings may provide a better understanding of the underlying mechanisms of skin cancer, which could lead to the development of more effective treatments.

These new findings provide hope and insight into the development of treatments that can help people with skin cancer. The research team is continuing to work on developing better therapies and treatments for this life-threatening disease.

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